The San Francisco 49ers were at home to play the Jacksonville Jaguars in week four. Entering math, the Ninas had a perfect 3-0 record. Brock Purdy is back in week 4 after missing two games due to toe and shoulder injuries.
He was 22-38 with 309 passing yards, two touchdowns and two interceptions. San Francisco took the Jaguars to the first defeat of the season, 26-21. On Monday afternoon, NFL Insiders reported that 49ers’ Brock Purdy was dealing with pain in his toes. The Niners will have a short week against the Rams on Thursday night. Purdy could miss the third game of the season if he can’t play.
Brockpurdy handles lingering toe injuries early in the 2025 season
#49ers QB Brock Purdy came today “sadly complaining of his toe pain,” according to Kyle Shanahan. Purdy and Shanahan spoke on the phone last night. Purdy said there were no issues during the game.
– Nick Wagoner (@nwagoner) September 29, 2025
After a 17-13 victory in Week 1 with the Seahawks vs. Seahawks, Brock Purdy of the 49ers dealt with shoulder and toe injuries. The 25-year-old missed two straight games for San Francisco. Backup QB Mac Jones started in week 2 and 3, helping the 49ers lead the victory. A few days before the fourth week game, QB Brock Purdy is back. He started off for the team in week 4, but San Francisco lost 26-21.
On Monday, NFL insider Nick Wagoner reported that Brock Purdy complained of pain in his toes. Coach Kyle Shanahan spoke with Purdy and said QB had no issues during the game. The team has already dealt with some injuries in the offense. San Francisco can’t afford to miss a Brock Purdy anytime.
Brock Purdy has 16 intercepts in his final 17 start#49ers pic.twitter.com/os4y1zjvci
– Chase Senior (@chase_senior) September 29, 2025
The team will quickly turn around in week 5. They’re heading down the road for Thursday night Football vs. Los Angeles Rams. If Purdy can’t play, Mac Jones will make their third start of the 2025 season. This is a key division matchup for NFC West. San Francisco is 2-0 in the division this season, winning against the Seahawks and Cardinals.
During his fourth week loss to the Jaguar, WR Ricky Pearsall suffered a knee injury. Kyle Shanahan has expressed long-term optimism for Pearsall, but the younger WR could be in Week 5 and for the Rams. Additionally, George Kittle is in IR and is not eligible to return until the sixth week. Will BrockPurdy be available for the 49ers in week 5? Their franchise QB deals with lingering toe injuries that they suffered in week one.
